Abstract: Introduction: The natural history of ocular manifestations is very poor in Behcet's Disease (BD). The lesions progress by successive attacks leading to sever loss of vision or blindness. Aggressive treatments, by the association of cytotoxic drugs and steroids, have dramatically changed the outcome. However, still some ophthalmologists are convinced that the improvement is temporary and in the long run the eyes progress toward blindness. The aim of this study was ...
Abstract: lntroduction: Ocular lesions of Behcet's Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Cytotoxic drugs are necessary for the treatment. A short-term study with azathioprine (AZA) was presented to the 8th lnternational Conference on Behcet's Disease. The aim of this study is to present the results for a longer period of time. Materials & methods: Patients (32) who received more than 9 months of treatment ...
Abstract: Introduction: The ocular lesions of Behcet's disease (BD) progress usually toward severe loss of vision or blindness, and therefore need aggressive treatment. However, even such a treatment is not always successful. We used classification and regression tree (cart) method to see if some factors could predict the result of the future treatment. Methods: Eight hundreds and thirty patients who fulfilled the Iran criteria for BD were selected for this study. They ...
Abstract: To study the effect of acetazolamide on Cystoid Macular Edema (CME) in patients with Behcet's disease, twenty three patients (46 eyes) who had chronic, but controlled uveitis associated cystoid macular edema were randomized into a double masked, cross - over trial comparing acetazolamide (250mg bid) versus placebo. Eighteen patients (36 eyes) completed the trial (11 males, 7 females). Although acetazolamide trial led to slightly better results in decreaing CME angiographically, over ...
Abstract: Introduction: Ocular lesions of Behcet’s Disease (BD) need aggressive treatment to prevent from severe loss of vision or blindness. Although cytotoxic drugs are thought to be the main therapeutic arsenal, no control study has yet been done to demonstrate their efficacy. This study was designed t evaluate the short-term efficacy of pulse cyclophosphamide in a randomized double blind control study. Materials & Methods: PCP was used as Ig per square meter ...
Abstract: Introduction: Posterior uveitis (PU) and retinal vasculitis (RV) are the main morbidity factor in Behcet’s Disease (BD). They usually progress toward severe loss of vision or blindness. They need aggressive treatment with cytotoxic drugs. Azathioprine was demonstrated, in a double blind control study, to be effective in Behcet’s Disease. The aim of this study was to evaluate the efficacy of Azathioprine in ocular lesions of BD, and to compare ...
Abstract: Introduction: Cytotoxic drugs are all effective in the treatment of ocular lesions of Behcet’s disease (BD). However, with all methods there are some patients that their eye lesions will progress despite the treatment. This study was designed to find whether a combination therapy with 2 of these drugs could have better effect in reducing the rate of non-responders. Materials & Methods: Twenty eight patients diagnosed as BD (according to the Iran ...
Abstract: Introduction: The geographical distribution of Behcet's Disease (B.D) is thought to be due to the predisposing factor(s) spread along the Silk Route. It is widely accepted that the predisposing factor(s) is of genetic origin. However the rarity of BD among Hawaiian's Japanese immigrants may be in favor of environmental factors. Iran is situated in the middle of the Silk Route. Caucasians account for 75.4%, Turks (from Mongoloid ethnic origin) for ...
Abstract: Introduction: Oral aphthosis (OA) is seen in 96% of patient with Behcet’s Disease (BB) OA is said to be rather frequent in the general population. It was therefore interesting to determine whether OA in the general population had also a genetic background as it is for BD. It was also interesting to determine if the genetic background was similar in both conditions (BD and OA in the general population). Therefore, ...
Abstract: Introduction: The etiology of Behcet's disease (BD) is unknown, but like other autoimmune disorders both environmental and genetic factors contribute to its pathophysiology. The familial form of BD is in favor of a genetic predisposition. This study was designed to evaluate the prevalence of the familial form and their possible effect on the disease expression in Iranian patients. Materials & Methods: We studied prospectively 1242 consecutive patients with ...